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目的探讨核因子κB(NF-κB)与血管内皮生长因子C(VEGF-C)在“三阴”型乳腺癌(TNBC)与“非三阴”型乳腺癌(N-TNBC)中的表达及其临床意义。方法应用免疫组织化学SP法检测TNBC患者(A组,76例)和N-TNBC对照患者(B组,128例)癌组织中NF-κB和VEGF-C的表达,分析其与临床病理特征的关系。结果两组NF-κB和VEGF-C表达均与肿瘤组织学分级、临床分期和淋巴结转移相关(P<0.05)。A组NF-κB和VEGF-C的阳性率分别为78.9%和67.1%,高于B组的71.1%和64.8%。两组NF-κB与VEGF-C的表达均呈正相关。结论 NF-κB与VEGF-C在TNBC中高表达,可能在促进肿瘤的生长、浸润及转移中起作用。
Objective To investigate the relationship between the expression of nuclear factor-κB (NF-κB) and vascular endothelial growth factor C (VEGF-C) in non-trigeminy type breast cancer (TNBC) In the expression and clinical significance. Methods The expressions of NF-κB and VEGF-C in TNBC patients (A group, 76 cases) and N-TNBC control group (B group, 128 cases) were detected by immunohistochemical SP method. relationship. Results The expressions of NF-κB and VEGF-C in both groups were correlated with tumor histological grade, clinical stage and lymph node metastasis (P <0.05). The positive rates of NF-κB and VEGF-C in group A were 78.9% and 67.1%, respectively, which were higher than 71.1% and 64.8% in group B respectively. Both NF-κB and VEGF-C expression were positively correlated. Conclusion The high expression of NF-κB and VEGF-C in TNBC may play a role in promoting tumor growth, invasion and metastasis.