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连续五天给Wistar种断乳雄性大鼠以50mg/kg每天灌胃工业品杀螟松(日本大阪Sumitomo化学公司生产的97%纯品)花生油溶液。多数动物于第三次灌胃后1小时内出现中度中毒症状。第五天后则出现全身性震颤和阵发性痉挛的严重中毒症状。四天后症状消失。工业品杀螟松对大鼠急性经口LD_(50)为242～740 mg/kg,杀螟松花生油溶液对雄性大鼠的急性经口LD_(50)约为900 mg/kg。大鼠连续灌胃三天杀螟松(50 mg/kg/天)后,红血球乙酰胆硷酯酶(AchE)、血浆假胆硷酯酶(PchE)、肝肾脂族酯酶(AliE)及脑
Male Wistar weanling male rats were orally administered with industrial fenitrothion (97% pure product manufactured by Sumitomo Chemical Co., Ltd., Osaka, Japan) peanut oil solution at a daily rate of 50 mg / kg for five consecutive days. Most animals showed moderate symptoms of poisoning within 1 hour after the third gavage. After the fifth day there are generalized tremor and paroxysmal spasms of severe poisoning symptoms. Four days later the symptoms disappeared. The acute oral LD 50 value of industrial fenitrothion in rats was 242 ~ 740 mg / kg. The acute oral LD 50 of fenitrothion peanut oil solution was about 900 mg / kg in male rats. After continuous administration of fenitrothion (50 mg / kg / day) to rats, the AchE, PchE, AliE, brain