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利用XbaⅠ限制性内切酶、墨迹杂交对24例正常人及35例NIDDM患者的白细胞基因组DNAGT基因进行了分析。结果显示了X_1 5.4kb、X_2 5.0kb 两个多态性的片段。统计学处理表明X_1、X_2等位基因频率及基因型频率在正常人及NIDDM 患者之间的分布无显著性差异,因而此多态性尚不能作为NIDDM 患者的遗传标志,提示GT 基因和NIDDM 之间可能没有关联。
The leukocyte genomic DNA GT gene was analyzed by Xba I restriction endonuclease and ink blot in 24 normal subjects and 35 NIDDM patients. The results showed two polymorphic fragments X_1 5.4kb and X_2 5.0kb. Statistical analysis showed that there was no significant difference in the distribution of X_1 and X_2 alleles between normal subjects and NIDDM patients. Therefore, this polymorphism can not be used as a genetic marker for patients with NIDDM, suggesting that GT gene and NIDDM May not be related.