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全世界范围内血源紧张、病毒污染等问题推动了血液代用品的研究。各种修饰血红蛋白、氟碳乳剂、血红蛋白微囊等技术迅速发展,其中一些已经形成规模化制备工艺。但是,对于血液代用品目前没有完整的评价体系,全面评估血液代用品产品仍较困难。本文根据国内外血液代用品的研究现状和最新进展,重点从血液代用品的评价角度出发,探讨血液代用品的评价参数,围绕血液代用品的理化性质、有效性与安全性、保存条件等方面进行了综述。
Worldwide blood supply problems, virus contamination and other issues have promoted the study of blood substitutes. A variety of modified hemoglobin, fluorocarbon emulsion, hemoglobin microcapsules and other rapid development of technology, some of which have formed a scale of the preparation process. However, there is currently no complete evaluation system for blood substitutes, and it is still more difficult to evaluate blood substitute products in an all-round way. Based on the research status and the latest progress of blood substitutes at home and abroad, this article focuses on the evaluation parameters of blood substitutes, focusing on the evaluation of blood substitutes, focusing on the physical and chemical properties, effectiveness and safety of blood substitutes, storage conditions, etc. Reviewed.