【摘 要】
：
目的 探讨伴视空间功能障碍的帕金森病(Parkinson disease,PD)患者低频振幅(amplitude of low-frequency fluctuations,ALFF)变化特点,以揭示视空间功能障碍相关脑区的神经元
【机 构】
：
230001 合肥 中国科学技术大学附属第一医院神经电生理室、神经外科;中国科学技术大学附属第一医院神经外科、脑功能与脑疾病安徽省重点实验室、安徽省脑立体定向神经外科研究所;中国科学技术大学附属第一医
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目的 探讨伴视空间功能障碍的帕金森病(Parkinson disease,PD)患者低频振幅(amplitude of low-frequency fluctuations,ALFF)变化特点,以揭示视空间功能障碍相关脑区的神经元活动和可能有关的神经病理学机制.方法 纳入32例帕金森病患者(PD),所有受试者均完成画钟试验(clock drawing test,CDT)、简易智能精神状态检查量表(mini—mental state examination,MMSE)、蒙特利尔认知评估量表(montreal cognitive assessment,MoCA)、数字广度测试(digit span test,DSPT)、动物词汇流畅性测验(verbal fluency test,VFT)等认知检查,分为视空间功能障碍(PD—V组)18例,视空间功能正常组(PD—N组)14例.受试者于静息状态下利用GE磁共振扫描采集静息态fMRI数据,计算指标低频振幅(ALFF),统计分析差异脑区.结果 PD—V组患者MMSE总得分(P=0.018)、MoCA 得分(P=0.000)、DSPT评分(P=0.000)、VFT 评分(P=0.023)均低于 PD—N 组,差异具有统计学意义(均P＜0.05).PD-V组ALFF值升高脑区主要位于左额上回、右角回/顶上回(GRF校正,voxel P＜0.05,cluster P＜0.05,cluster size＞555 voxels).结论 帕金森病伴视空间功能障碍患者存在认知功能损害,左额上回、右角回/顶上回的神经元活动增强,可能是对视空间功能障碍的适应和代偿.
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