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目的探讨HLA基因多态性与肝癌遗传易感性的关系。方法应用LDR-PCR方法对2013年7月至2016年3月间确诊的322例肝细胞癌患者和同期310例正常体检者HLA基因的两个单核苷酸多态性位点H L A-D R B1(rs9269186)、H L A-D R B1(rs201540428)进行基因型检测。结果与对照组相比,肝细胞癌患组HLA-DRB1(rs9269186)G/G基因型或G等位基因(C/G+G/G)显著升高(OR=2.20,95%CI=1.04-4.66,P<0.05;OR=1.44,95%CI=1.04-1.99,P<0.05),未发现HLA-DRB1(rs201540428)多态性与HCC的显著相关性。结论 rs9269186G可能是肝细胞癌发生的危险因素。
Objective To investigate the relationship between HLA gene polymorphism and genetic susceptibility to liver cancer. METHODS: Two single nucleotide polymorphisms (SNPs) of HLA genes in 322 hepatocellular carcinoma patients and 310 normal controls diagnosed between July 2013 and March 2016 were analyzed by LDR-PCR. (rs9269186), HL AD R B1 (rs201540428) for genotyping. Results Compared with the control group, HLA-DRB1 (rs9269186) G / G genotype or G allele (C / G + G / G) were significantly increased in HCC patients (OR = 2.20, 95% CI = 1.04 -4.66, P <0.05; OR = 1.44, 95% CI = 1.04-1.99, P <0.05). No significant association between HLA-DRB1 (rs201540428) polymorphism and HCC was found. Conclusion rs9269186G may be a risk factor for hepatocellular carcinoma.