Synthesis and Anti-HIV Activity of Trisubstituted (3'R, 4'R)-3',4'- Di-O-(S)-cam

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To further explore the potential of DCK analogs as anti-HIV drug candidates, ten new tri-substituted (3R,4R)-3,4-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives (4-13)were designed, synthesized, and evaluated against HIV replication in MT4 cells and H9 lymphocytes.
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