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目的筛选四氯化碳(CCl4)致小鼠急性肝损伤最佳模型,并研究一枝蒿有效部位(AR)对CCl4所致小鼠急性肝损伤的保护作用。方法采用不同浓度的CCl4花生油溶液予小鼠腹腔注射,测定小鼠血清中天冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)的含量。一枝蒿有效部位予小鼠连续灌胃5 d,用最佳CCl4模型造成小鼠急性肝损伤,测定小鼠血清中ALT和AST的含量,观察光镜下小鼠肝组织的病理变化。结果 0.11%CCl4模型组为最佳模型。AR低、中、高剂量组均能抑制CCl4引起的急性肝损伤所致的ALT、AST升高。结论 AR对CCl4所致急性肝损伤的小鼠有保护作用。
Objective To screen the best model of acute liver injury induced by carbon tetrachloride (CCl4) in mice and to study the protective effect of effective fractions of Artemisia annua L. (AR) on acute liver injury induced by CCl4 in mice. Methods The mice were injected intraperitoneally with different concentrations of CCl4 peanut oil solution to determine the contents of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in mice serum. The effective area of Artemisia annua was given to mice continuously for 5 days. The best CCl4 model was used to induce the acute liver injury in mice. The levels of ALT and AST in the serum of mice were measured. The pathological changes of liver were observed under light microscope. Results 0.11% CCl4 model group as the best model. AR low, medium and high dose groups can inhibit CCl4 caused acute liver injury caused by ALT, AST increased. Conclusion AR has a protective effect on mice with CCl4-induced acute liver injury.