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目的探讨天门冬氨酸氨基转移酶线粒体型同工酶(m-AST)活性在肝脏疾病诊断中的应用价值。方法采用免疫抑制法对41例健康正常人及138例不同肝病患者进行m-AST活性测定。结果不同肝脏病症患者m-AST的活性都明显高于健康对照组,且与AST变化呈正相关。治疗2~3周后,急性肝炎随着肝功能的恢复,m-AST明显下降,与入院时比较有显著差异性(P<0.01);而慢性肝炎、肝硬化代偿期、原发性肝癌治疗前后,m-AST活性变化不明显;肝硬化失代偿期随着肝功能进一步损伤,治疗后m-AST仍持续不降,且有上升。结论检测并动态观察肝脏疾病患者的m-AST活性,对于了解肝脏疾病的病理生理变化,鉴别急、慢性肝炎,评价疗效、判断肝病预后,有着重要的临床意义。
Objective To investigate the value of mitochondrial isoenzyme (m-AST) activity of aspartate aminotransferase in the diagnosis of liver diseases. Methods Immunosuppression was used to determine the m-AST activity in 41 healthy controls and 138 patients with different liver diseases. Results The activity of m-AST in patients with different liver diseases were significantly higher than those in healthy controls and positively correlated with the changes of AST. After 2 to 3 weeks of treatment, m-AST decreased significantly with the recovery of liver function in acute hepatitis, which was significantly different from that at admission (P <0.01); while chronic hepatitis, decompensated liver cirrhosis, primary liver cancer Before and after treatment, m-AST activity did not change significantly; decompensation of liver cirrhosis with further damage to liver function, m-AST after treatment continued to decline, and increased. Conclusions The detection and dynamic observation of m-AST activity in patients with liver diseases has important clinical significance in understanding the pathophysiological changes of liver disease, identifying acute and chronic hepatitis, evaluating the curative effect and judging the prognosis of liver disease.