论文部分内容阅读
目的研究葛根素对糖尿病大鼠的肾脏保护作用。方法 SD大鼠分为正常对照组、糖尿病组、糖尿病大鼠葛根素干预组。以高糖高脂饮食及小剂量连脲佐菌素(30mg/kg)制备2型糖尿病大鼠模型。24周后检测Ⅳ型胶原的蛋白表达。结果Ⅳ型胶原的表达在糖尿病组大鼠显著高于正常对照组,治疗组较糖尿病组明显下降。结论在2型糖尿病大鼠中,葛根素可降低Ⅳ型胶原的表达,延缓糖尿病肾病的发生。
Objective To study the protective effects of puerarin on diabetic rats. Methods SD rats were divided into normal control group, diabetic group and diabetic rat puerarin intervention group. Type 2 diabetic rat model was induced by high glucose and high fat diet and low dose of streptozotocin (30mg / kg). After 24 weeks, the protein expression of type Ⅳ collagen was detected. Results The expression of type Ⅳ collagen in diabetic rats was significantly higher than the normal control group, the treatment group was significantly lower than the diabetic group. Conclusion In type 2 diabetic rats, puerarin can reduce the expression of type Ⅳ collagen and delay the occurrence of diabetic nephropathy.