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目的 对比分析急性低压缺氧对青年、老龄大鼠血浆和大脑皮质中内皮素 (ET)、一氧化氮 (NO)含量和大脑皮质光、电镜形态学的影响。 方法 将 2 6只 2月龄和 2 6只 2 2月龄雄性 Wis-tar大鼠各随机分成对照组和缺氧组。急性低压缺氧 (80 0 0 m,30 min)后测定各组血浆和大脑皮质匀浆中 ET、NO的含量 ,观察大脑皮质光、电镜形态学的变化。 结果 急性重度低压缺氧后青年、老龄大鼠血浆和大脑皮质中 ET、NO含量明显升高 (P<0 .0 1或 P<0 .0 5 ) ,大脑皮质发生水肿、变性等损害。老龄大鼠缺氧后 ET、NO升高的幅度比青年大鼠更明显 ,其缺氧性脑水肿损害也比青年大鼠重。 结论 老龄大鼠比青年大鼠对急性缺氧更为敏感。ET、NO可能参与了缺氧性脑损害的病理过程。
OBJECTIVE: To compare the effects of acute hypobaric hypoxia on plasma and cerebral cortex in young and aged rats with endothelin (ET), nitric oxide (NO) content and light and electron microscope morphological changes. Methods Twenty-six 2-month-old and 26 2-month-old male Wis-tar rats were randomly divided into control group and hypoxia group. After acute hypobaric hypoxia (80 000, 30 min), the contents of ET and NO in plasma and cerebral cortex homogenate of each group were measured, and the changes of light and electron microscope morphology were observed. Results After acute hypobaric hypoxia, the content of ET and NO in plasma and cerebral cortex of aged and aged rats were significantly increased (P <0.01 or P <0.05), and the edema and degeneration of cerebral cortex were found. After aging, hypoxia, ET, NO increased more significantly than young rats, hypoxic brain edema damage than young rats. Conclusion Aged rats are more sensitive to acute hypoxia than young rats. ET and NO may participate in the pathological process of hypoxic brain damage.