Background:Although visceral leishmaniasis(VL),a disease caused by parasites,is controlled in most provinces in China,it is still a serious public health problem and remains fundamentally uncontrolled in some northwest provinces and autonomous regions.The objective of this study is to explore the spatial and temporal characteristics ofVL in Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region in China from 2004 to 2018 and to identify the risk areas for VL transmission.rnMethods:Spatiotemporal models were applied to explore the spatio-temporal distribution characteristics of VL and the association between VL and meteorological factors in western China from 2004 to 2018.Geographic information of patients from the National Diseases Reporting Information System operated by the Chinese Center for Disease Control and Prevention was defined according to the address code from the surveillance data.rnResults:During our study period,nearly 90％of cases occurred in some counties in three western regions(Sichuan Province,Gansu Province and Xinjiang Uygur Autonomous Region),and a significant spatial clustering pattern was observed.With our spatiotemporal model,the transmission risk,autoregressive risk and epidemic risk of these coun-ties during our study period were also well predicted.The number of VL cases in three regions of western China concentrated on a few of counties.VL in Kashi Prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic areas.rnConclusions:The number ofVL cases in three regions of western China concentrated on a few of counties.VL in Kashi Prefecture,Xinjiang Uygur Autonomous Region is still serious prevalent,and integrated control measures must be taken in different endemic areas.Our findings will strengthen the VL control programme in China.