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目的：研究维Ａ酸（Ｔｒｅ）或维生素Ａ（Ｒｅｔ）对膀胱肿瘤患者淋巴因子激活的杀伤细胞（ＬＡＫ细胞）的增殖和对膀胱肿瘤细胞的细胞毒作用．方法：分别用细胞计数和ＭＴＴ法测定ＬＡＫ细胞的增殖和细胞毒作用．结果：Ｔｒｅ或Ｒｅｔ１０－１００ｎｍｏｌ·Ｌ－１加强由白细胞介素２（ＩＬ２）诱导的ＬＡＫ细胞的增殖和对膀胱肿瘤细胞的杀伤作用．结论：Ｔｒｅ或Ｒｅｔ增强膀胱肿瘤患者ＬＡＫ细胞增殖及对膀胱肿瘤的细胞毒作用．
Objective: To study the proliferation of lymphokine-activated killer cells (LAK cells) and the cytotoxic effect on bladder tumor cells in patients with bladder tumors with tretinoin (Tre) or vitamin A (Ret). METHODS: The proliferation and cytotoxicity of LAK cells were determined by cell counting and MTT assay, respectively. RESULTS: Tre or Ret10-100 nmol·L-1 enhanced the proliferation of LAK cells induced by interleukin-2 (IL-2) and the killing effect on bladder tumor cells. CONCLUSION: Tre or Ret enhances LAK cell proliferation and cytotoxicity to bladder tumor in bladder cancer patients.