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目的:检测胃癌组织中DNA损伤修复酶(O6—甲基鸟嘌呤—DNA甲基转移酶O6—methylguanineDNA methyltransferase,MGMT)的表达变化,探讨其表达和胃癌临床病理特征之间的关系,进一步用于指导临床化疗方案的制定。方法:采用免疫组化方法(SABC法)检测55例胃癌标本中MGMT的表达情况。结果:MGMT在胃癌组织中的阳性表达率为43.64%(24/55),其阳性表达与年龄、病理类型有关,而与性别`、分化程度、侵犯深度、淋巴结转移的相关性不明显。结论:MGMT对胃癌化学治疗方案的制定有指导作用。
OBJECTIVE: To detect the expression of O6-methylguanine-DNA methyltransferase (MGMT) in gastric cancer tissue and to explore its relationship with the clinicopathological features of gastric cancer, Guide the development of clinical chemotherapy program. Methods: The expression of MGMT in 55 cases of gastric cancer was detected by immunohistochemistry (SABC method). Results: The positive expression rate of MGMT in gastric cancer was 43.64% (24/55). The positive expression of MGMT was related to age and pathological type, but not to the gender, differentiation, invasion depth and lymph node metastasis. Conclusion: MGMT can guide the development of chemotherapy regimen of gastric cancer.