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目的:用改良GBI法检测观察乳腺癌、癌旁,乳腺增生性病变及其远离病变部位的正常乳腺小叶中C-erbB-2的表达情况、表达类型及意义。结果:28例乳腺癌C-erbB-2的阳性染色主要在细胞膜上,阳性率为100%;23例癌旁增生导管与乳腺增生性病变阳性染色大部分在细胞浆内,阳性率为86.96%,仅有少部分在细胞膜上;病变周围的正常乳腺小叶均未见到膜染色反应,三者间存在明显差异(P<0.01)。结论:C-erbB-2癌蛋白的膜型还是胞浆型表达可以作为乳腺癌与乳腺增生性病变鉴别诊断的重要指标之一。
OBJECTIVE: To observe the expression of C-erbB-2 in normal breast lobules of breast cancer, paracancer, breast hyperplastic lesions and its far away lesions by modified GBI method and its significance. Results: The positive staining of C-erbB-2 was mainly in the cell membrane in 28 cases of breast cancer. The positive rate was 100%. The positive staining of 23 cases with paracancerous ductal hyperplasia and hyperplasia of mammary gland was mostly in the cytoplasm with a positive rate of 86%. 96%, only a small part of the cell membrane; lesion around the normal breast lobular membrane staining reaction was not seen, there was a significant difference between the three (P <0.01). Conclusion: The membrane-type or cytoplasmic expression of C-erbB-2 oncoprotein can be used as one of the important markers in differential diagnosis of breast cancer and breast hyperplasia lesions.