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尼莫地平治疗急慢性脑血管病有一定效果,我们以往的实验也表明尼莫地平可预防或延缓卒中型自发性高血压大鼠(SHRsp)脑卒中的发生。本实验目的是了解尼莫地平对SHRsp血液流变学有关指标的影响,以进一步探索其抗卒中作用的机制。 实验动物是从美国引进在本院繁育的第9代雌性SHRsp,大鼠自由食标准饲料,饮1％NaCl盐水。将大鼠随机分为治疗组(n=14)和对照组(n=16)。治疗组用尼莫地平30mg·kg~(-1)·d~(-1)拌入少量碎食中喂,治疗3周;对照组仅喂同等量碎食。治疗前及治疗后第3周用尾套法(上海大鼠血压仪)各测1次收缩压及心率,并测体重。治疗3周末用乙醚麻醉大鼠,开胸取心腔血4ml,测定全血粘度(锥板法)、血浆粘度(锥板法)、血细胞
Nimodipine treatment of acute and chronic cerebrovascular disease has some effect, our previous experiments also showed that nimodipine can prevent or delay the onset of stroke-induced spontaneous hypertensive rats (SHRsp) stroke. The purpose of this experiment is to understand the effect of nimodipine on the index of hemorrheology in SHRsp so as to further explore its anti-stroke mechanism. The experimental animals were imported from the United States in the 9th generation of female SHRsp breeding in our hospital, rats fed free standard diet, drink 1% NaCl saline. The rats were randomly divided into treatment group (n = 14) and control group (n = 16). The treatment group was treated with nimodipine 30 mg · kg -1 d -1 for 3 weeks and the control group was fed the same amount of food. Before treatment and 3 weeks after treatment with tail cuff method (Shanghai rat blood pressure meter) each measured systolic blood pressure and heart rate, and measured body weight. After 3 weeks of treatment, rats were anesthetized with ether and thoracotomy cardioplegia 4ml. Whole blood viscosity (cone plate method), plasma viscosity (cone plate method), blood cells