GOT和GPT在肝细胞内含量非常丰富,当肝细胞受损时将大量逸出,进入血液。因此,血清GOT,GPT常被作为反映急性肝实质性损伤的灵敏指标。葡萄糖-6-磷酸脱氢酶(G-6-P)定位于肝细胞滑面内质网,而后者又与毒物代谢转化有关。在肝毒理学研究中常将肝匀浆G-6-P作为观察指标。关于大鼠以上三种生化指标的正常值虽已有报道,但有的所用动物数甚少(15～30只),有的甚至不管资料属何种分 GOT and GPT are highly abundant in hepatocytes and escape large amounts into the bloodstream when hepatocytes are damaged. Therefore, serum GOT, GPT is often used as a sensitive indicator of acute liver parenchymal injury. Glucose-6-phosphate dehydrogenase (G-6-P) is localized to the endoplasmic reticulum of hepatocytes, which in turn is involved in metabolic transformation of toxins. In liver toxicology often liver homogenate G-6-P as an indicator. Although the normal values ​​of the above three biochemical indexes in rats have been reported, some animals are few (15-30), and some even no matter what kind of data