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皮肤感染性疾病发病率高,严重危害人类健康。因口服或注射给药可引起中枢神经系统等不良反应,在治疗皮肤感染性疾病时,多采用外用剂型。甲硝唑对引起皮肤感染性疾病的敏感菌具有抑制作用,甲硝唑外用具有用药量小、局部药物浓度高、作用持久、不良反应少和使用方便等优点,在治疗皮肤科疾病中具有广阔的应用前景。现主要综述甲硝唑在治疗皮肤疾病中的应用概况,为甲硝唑外用剂型的研发提供理论支持。
The incidence of skin infectious diseases is high, seriously endangering human health. Due to oral or injection can cause central nervous system and other adverse reactions, in the treatment of skin infections, the use of topical dosage forms. Metronidazole has the inhibitory effect on the sensitive bacteria causing the skin infectious diseases. Metronidazole topical has the advantages of small dosage, high concentration of local drug, long lasting effect, less adverse reactions and easy to use, etc., which has a wide range in the treatment of dermatological diseases The application prospects. Now I mainly review the application of metronidazole in the treatment of skin diseases, providing theoretical support for the development of metronidazole topical formulations.