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应用免疫组织化学法测定增殖细胞核抗原（ＰＣＮＡ）及电镜观察，了解Ｈ及Ｌ铁蛋白分别对人上皮性卵巢癌细胞株ａｏ及３ａｏ增殖组分及超微结构的影响。结果：发现Ｈ及Ｌ铁蛋白均使ａｏ及３ａｏ细胞增殖组分减少（Ｐ＜０．０５）。并发现：Ｈ及Ｌ铁蛋白可使ａｏ及３ａｏ细胞线粒体及糖原颗粒减少，溶酶体及脂滴增加。Ｈ铁蛋白还可使细胞内质网排列紊乱，部分扩张，核糖体脱失并使细胞核固缩；核膜皱缩及异染色质增加，边聚。提示：铁蛋白，特别是Ｈ铁蛋白，可使卵巢癌细胞增殖降低并使其能量代谢及蛋白质合成发生障碍，细胞自身清除作用增强，使核趋向不活跃。因此，可能铁蛋白作为一种抑素样物质，对卵巢癌细胞的增殖起抑制作用。
The proliferating cell nuclear antigen (PCNA) and electron microscopy were used to observe the effect of H and L ferritin on proliferation and ultrastructure of human epithelial ovarian cancer cell lines ao and 3ao respectively. Results: It was found that both H and L ferritin decreased the proliferation components of ao and 3ao cells (P <0.05). And found: H and L ferritin ao and 3ao cells can reduce mitochondria and glycogen granules, lysosomes and lipid droplets increased. H ferritin can also make the cell endoplasmic reticulum disarranged, partially expanded, ribosomes loss and nuclear condensation; nuclear shrinkage and heterochromatin increase, edge poly. Tip: Ferritin, especially ferritin, can reduce the proliferation of ovarian cancer cells and make its energy metabolism and protein synthesis obstacles, the cell self-scavenging effect, so that the nucleus tends to be inactive. Thus, it is possible that ferritin, as a somatostatin-like substance, inhibits the proliferation of ovarian cancer cells.