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应用放射免疫分析法测定了肝病患者的血清透明质酸和血清催乳素的含量。测定结果表明:(1)慢性肝炎及肝硬化患者血清透明质酸含量均比正常对照组明显增高,有非常显著性差异(P<0.01)。肝损害越严重者,血清透明质酸升高越明显。血清透明质酸可作为慢性活动性肝炎和早期肝硬化的预测指标。(2)肝硬化患者的血清催乳素比正常对照组明显增高。血清催乳素可以作为肝硬化的一项辅助化验指标。此外,对肝病患者血清透明质酸和血清催乳素含量变化的机理进行了讨论。
Radioimmunoassay was used to determine the levels of serum hyaluronic acid and serum prolactin in patients with liver diseases. The results showed that: (1) The levels of serum hyaluronic acid in patients with chronic hepatitis and cirrhosis were significantly higher than those in normal controls (P <0.01). The more severe liver damage, the more obvious increase in serum hyaluronic acid. Serum hyaluronic acid can be used as a predictor of chronic active hepatitis and early cirrhosis. (2) serum prolactin in patients with cirrhosis was significantly higher than the normal control group. Serum prolactin can serve as a secondary laboratory test for cirrhosis. In addition, the mechanism of the changes of serum hyaluronic acid and serum prolactin in patients with liver diseases is discussed.