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成纤维细胞生长因子(Fibroblast GrowthFactor,FGF)以酸性分子和碱性分子两种形式存在,它能触发一系列中胚层及神经外胚层来源细胞的增生与分化。本文就 FGF 研究的最新进展分为 FGF 的生物化学、FGF 基因、FGF受体及其在体内外的生物学作用加以论述。FGF 的生物化学牛脑及其垂体中的 FGF 已被纯化,其特性亦已研究清楚。FGF 的碱性形式的 pI 为9.6,而酸性 FGF 的 pI 为5.6～6.0,酸性及碱性FGF 均不耐酸和热,因此,要分离得到它们的
Fibroblast Growth Factor (FGF) exists in two forms, acidic and basic. It can trigger a series of proliferation and differentiation of mesoderm and neuroectodermal cells. In this article, the latest advances in FGF research are divided into FGF biochemistry, FGF genes, FGF receptors and their biological effects in vivo and in vitro. FGF Biochemistry The FGFs in the bovine brain and pituitary have been purified and their properties have been studied. The basic form of FGF has a pI of 9.6, while acidic FGF has a pI of 5.6 to 6.0. Both acidic and basic FGF are not acid and heat resistant, so they are isolated.