论文部分内容阅读
作者对912名生自HBsAg阴性母亲的婴儿,随机按0、1、3月(A组)和0、1、6月(B组)程序接种重组乙型肝炎(HB)疫苗10μg,A及B组分别为275和637例。在出生时、1月龄和4～7月龄接种对象均采血2ml。第3剂后15～18月龄,对A组144例和B组201例采集血标本,以ELISA测定血清抗-HBs水平。抗-HBs分四类:<2mIU/ml为无应答;2.1～9.9mIU/ml为低应答;10～100mIU/ml为有应答;>100mIU/ml为高应答。10mIU/ml为有应答与无应答的分界线。 3针后1个月,抗-HBs>10mIU/ml者为98.1％(895/912),无应答者1.9％(17/912);抗-HBs>100mIU/ml者A及B组分别有
The authors vaccinated 912 HBsAg-negative mothers of infants randomly assigned to receive 10 μg of the recombinant hepatitis B (HB) vaccine in cycles 0, 1 and 3 (group A) and 0, 1 and 6 months (group B), A and B The group was 275 and 637 cases, respectively. At birth, 1-month-old and 4 to 7-month-old vaccinated subjects were collected blood 2ml. Blood samples were collected from 144 cases in group A and 201 cases in group B after 15 to 18 months after the third dose, and the level of anti-HBs in serum was measured by ELISA. Anti-HBs divided into four categories: <2mIU / ml is no response; 2.1 ~ 9.9mIU / ml is low response; 10 ~ 100mIU / ml is a response;> 100mIU / ml is a high response. 10mIU / ml with and without response to the dividing line. One month after the 3-pin treatment, 98.1% (895/912) of anti-HBs> 10mIU / ml and 1.9% (17/912) of non-responders showed anti-HBs> 100mIU /