1950年Steinhous等根据兔及犬的药理实验结果提出:(一)镇静剂量的戊巴比妥钠5mg/kg(1/6麻醉剂量),不能预防可卡因中毒:只有在15mg/kg(1/2麻醉剂量)时,才有预防作用。 (二)给了戊巴比妥钠预防的动物,当静脉注射可卡因发生中毒及呼吸停止时,其动脉压较对照组(未给戊巴比妥钠者)为低。例如5只曾注射戊巴比妥钠(15mg/kg)的犬可卡因中毒时,血压 In 1950, Steinhous et al. Proposed the following pharmacological experiments in rabbits and dogs: (1) Sedative dose of sodium pentobarbital 5 mg / kg (1/6 anesthetic dose) can not prevent cocaine poisoning: only at 15 mg / kg Anesthetic dose), only a preventive effect. (B) Animals given prophylactic sodium pentobarbitol had lower arterial pressure than those in the control group (those not given sodium pentobarbital) when intravenous injection of cocaine poisoned and stopped breathing. For example, 5 dogs who had been injected with pentobarbital sodium (15 mg / kg) had cortical blood pressure when cocaine poisoned