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目的:研究丹参喷鼻剂对实验性脑缺血的保护作用。方法:采用大鼠MCAO模型分别观察对大鼠脑内梗死面积的影响,对大鼠抗疲劳的影响及大鼠微循环的影响,测定其相关指标。结果:比较于模型对照组神经行为学评分(2.20±0.82),丹参喷鼻剂中剂量组(1.52±0.46)和高剂量组(1.38±0.41)均可显著地改善大鼠的行为障碍(P<0.05);比较于模型对照组(20.86±4.23)%,丹参喷鼻剂高剂量组(14.93±4.27)%可显著性减少大鼠脑梗死面积(P<0.05);丹参喷鼻剂高剂量组大鼠游泳时间(16.51±5.82)min长于模型对照组(9.83±3.15)min,差异有统计学意义(P<0.05);丹参喷鼻剂高剂量组滴Ad后微动脉管径缩小值(2.72±1.53)μm与模型对照组(3.40±3.22)μm相比较,差异也有统计学意义(P<0.05)。结论:丹参喷鼻剂对实验性脑缺血具有保护作用。
Objective: To study the protective effect of Danshen nasal spray on experimental cerebral ischemia. Methods: The rat MCAO model was used to observe the effect on the cerebral infarction area, the anti-fatigue effect and the microcirculation in rats, and the related indexes were measured. Results: Compared with the model control group, the neurobehavioral score (2.20 ± 0.82), Danshen nasal spray medium dose group (1.52 ± 0.46) and the high dose group (1.38 ± 0.41) can significantly improve the behavioral disorders in rats <0.05). Compared with the model control group (20.86 ± 4.23)%, the Danshen nasal spray high dose group (14.93 ± 4.27)% could significantly reduce the area of cerebral infarction in rats (P <0.05) (16.51 ± 5.82) min in model group was longer than that in model control group (9.83 ± 3.15) min, the difference was statistically significant (P <0.05) 2.72 ± 1.53 μm compared with the model control group (3.40 ± 3.22) μm, the difference was also statistically significant (P <0.05). Conclusion: Salvia nasal spray has a protective effect on experimental cerebral ischemia.