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目的观察紫杉醇洗脱支架治疗冠心病的临床实际疗效。方法297例患者接受紫杉醇洗脱支架治疗,均接受了临床随访,134例于支架置入术后5~15个月行冠状动脉造影随访。结果冠状动脉造影随访时,晚期管腔丢失支架内显著高于支架近端边缘及支架远端边缘(分别为0·37、0·18和0·12mm),再狭窄率为10·4%,以支架内弥漫性狭窄为主,再血管化率为6·7%。1例患者于支架置入后4个月发生猝死,发生率为0·34%。1例于支架置入后5天发生支架内亚急性血栓形成,发生率0·34%。晚期血栓形成2例(术后12~24个月),主要心血管不良事件发生率1·35%。结论紫杉醇药物洗脱支架对复杂冠脉病变有较好的疗效,能显著降低支架后再狭窄率及靶血管的再血管化率。
Objective To observe the clinical efficacy of paclitaxel-eluting stent in the treatment of coronary heart disease. Methods A total of 297 patients undergoing paclitaxel - eluting stent were enrolled in this study. All the patients were followed up for coronary angiography at 5-15 months after stent implantation. Results During follow-up of coronary angiography, the late luminal stent was significantly higher than the proximal and distal edges of the stent (0.37, 0.18 and 0.12 mm, respectively) and the restenosis rate was 10.4% Mainly diffuse stenosis, revascularization rate was 6.7%. One patient died of sudden death 4 months after stent implantation, the incidence was 0.34%. One case had subacute thrombosis within 5 days after stent placement, with a incidence of 0.34%. There were 2 cases of advanced thrombosis (12 to 24 months after operation), and the incidence of major cardiovascular adverse events was 1.35%. Conclusion Paclitaxel-eluting stent has a good curative effect on complex coronary lesions, which can significantly reduce the rate of restenosis and the rate of revascularization of target vessel.