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对32例老年慢性肺心病及30例正常人外周血自然杀伤细胞(NK细胞)活性进行检测,结果表明,老年慢性肺心病患者NK细胞活性在急性加重期或缓解期均明显低于正常人(P<0.01);且与患者病程长短无关(P>0.05),但急性加重期明显低于缓解期(P<0.01),伴有呼吸衰竭的肺心病患者NK细胞活性下降更为显著。提示慢性肺心病患者存在着细胞免疫功能障碍,NK细胞活性检测可以作为判断肺心病病情及预后的一个指标。
The activity of natural killer cells (NK cells) in 32 elderly patients with chronic cor pulmonale and 30 normal controls were determined. The results showed that the activity of NK cells in elderly patients with chronic pulmonary heart disease was significantly lower than that in normal subjects during acute exacerbation or remission P <0.01). And it had no relation with the duration of the disease (P> 0.05), but the acute exacerbation was significantly lower than that of the remission (P <0.01). The decline of NK cell activity was more significant in patients with pulmonary heart disease accompanied by respiratory failure. Prompted the existence of patients with chronic cor pulmonale of cellular immune dysfunction, NK cell activity can be used as a marker to determine the status of pulmonary heart disease and prognosis of an indicator.