How to simulate interior aerodynamic noise accurately is an important question of a car interior noise reduction.The unsteady aerodynamic pressure on body surfaces is proved to be the key effect factor of car interior aerodynamic noise control in high frequency on high speed.In this paper,a detail statistical energy analysis (SEA) model is built.And the vibra-acoustic power inputs are loaded on the model for the valid result of car interior noise analysis.The model is the solid foundation for further optimization on car interior noise control.After the most sensitive subsystems for the power contribution to car interior noise are pointed by SEA comprehensive analysis,the sound pressure level of car interior aerodynamic noise can be reduced by improving their sound and damping characteristics.The further vehicle testing results show that it is available to improve the interior acoustic performance by using detailed SEA model,which comprised by more than 80 subsystems,with the unsteady aerodynamic pressure calculation on body surfaces and the materials improvement of sound/damping properties.It is able to acquire more than 2 dB reduction on the central frequency in the spectrum over 800 Hz.The proposed optimization method can be looked as a reference of car interior aerodynamic noise control by the detail SEA model integrated unsteady computational fluid dynamics (CFD) and sensitivity analysis of acoustic contribution.