第十届国际药理学大会涉及神经药理的研究内容较多,现就神经肽、GABA和苯二氮(艹卓)类及其受体、阿片类、神经毒及其它中枢受体亚型的研究作一综合简介。 神经肽 神经肽近年发展较快,会上荷兰学者De Wied报告,神经肽一般存在于大的前体中,如ACTH和β-内啡肽存在于原阿片黑色素皮质素(POMC)。它参与多种神经功能的调节,如学习记忆。注意、觉醒和痛觉,对体温、血压、睡眠、呼吸和脑的代谢也有影响。澳大利亚Sexton和Men-delsohn报告了降钙素(CT)和降钙素相关肽(CGRP)不但可以引起RNA转录,而且在大鼠脑中还有特定的受体。利用放射自显影法发现中枢神经系统中存在着CT/CGRP受体的新亚型。英国Daw- The Tenth International Conference on Pharmacology involves more neuropsychopharmacological research, the study of neuropeptide, GABA and benzodiazepine and its receptors, opioids, neurotoxicity and other central receptor subtypes Make a comprehensive introduction. Neuropeptide neuropeptides have been developing rapidly in recent years. De Wied, a Dutch scholar at the conference, reported that neuropeptides are generally found in large precursors such as ACTH and beta-endorphin in the presence of pro-opioid melanocortin (POMC). It is involved in the regulation of many neurological functions, such as learning and memory. Note that awakening and pain are also affecting body temperature, blood pressure, sleep, breathing and brain metabolism. Sexton and Mendelsohn in Australia reported that calcitonin (CT) and calcitonin-related peptide (CGRP) not only cause RNA transcription, but also specific receptors in the rat brain. Using autoradiography found that there is a new subtype of CT / CGRP receptor in the central nervous system. United Kingdom Daw-