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目的探讨治疗急性加重期慢性阻塞性肺疾病的有效方案。方法 97例急性加重期慢性阻塞性肺疾病患者分为研究组(53例)与对照组(44例),所有患者均接受常规吸氧、解痉、平喘、祛痰、抗感染、改善通气等基础治疗,研究组在此基础上接受甲基强的松龙治疗,对照组在此基础上接受地塞米松治疗,现对比分析两组患者的疗效及不良反应发生率。结果研究组治疗效果显著优于对照组,两组比较差异有统计学意义(P<0.05)。研究组心悸、心律失常、食欲下降等不良反应发生率显著低于对照组,两组比较差异有统计学意义(P<0.05)。两组患者恶心呕吐发生率相比差异无统计学意义(P>0.05)。结论甲基强的松龙治疗急性加重期慢性阻塞性肺疾病的疗效确切,且安全性好,是急性加重期慢性阻塞性肺疾病的有效治疗药物之一。
Objective To investigate the effective treatment of acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 97 patients with acute exacerbation of chronic obstructive pulmonary disease were divided into study group (n = 53) and control group (n = 44). All patients received routine oxygen inhalation, antispasmodic, antiasthmatic, expectorant, anti-infection and ventilation And other basic treatment, the study group on the basis of methylprednisolone treatment, the control group on the basis of dexamethasone treatment, the efficacy of the two groups were compared and the incidence of adverse reactions. Results The study group was significantly better than the control group, the difference between the two groups was statistically significant (P <0.05). The incidence of adverse reactions such as heart palpitations, arrhythmia and loss of appetite were significantly lower in the study group than in the control group, with significant difference between the two groups (P <0.05). There was no significant difference in the incidence of nausea and vomiting between the two groups (P> 0.05). Conclusion Methylprednisolone is effective in the treatment of chronic obstructive pulmonary disease (COPD) in acute exacerbation. It is also one of the effective therapies in acute exacerbation of chronic obstructive pulmonary disease.