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[目的]通过观察隆起糜烂性胃炎(Raised Erosive Gastritis,REG)中医证型与幽门螺杆菌(Hp)感染和p53、增殖细胞核抗原(PCNA)表达之间的关系,以期更好的协助指导中西医结合防治REG。[方法]选择REG中医辨证符合脾胃湿热证、脾胃气虚证、脾虚湿热证的患者63例,并设正常对照(正常)组18例,所有受试者均行胃镜检查,取胃窦部活检标本行快速尿素酶试验及组织染色法检测Hp及p53、PCNA。[结果]REG组各证型的p53、PCNA表达均较正常组增加(均P<0.01);各证型的p53、PCNA阳性表达分别比较差异均无统计学意义(均P>0.05);各证型Hp阳性与Hp阴性者p53、PCNA阳性表达比较差异均无统计学意义(均P>0.05)。[结论]REG胃黏膜处于高增殖状态。REG中医各证型间与Hp感染及p53、PCNA表达无明显差异。
[Objective] To observe the relationship between traditional Chinese medicine (TCM) syndrome and Helicobacter pylori (Hp) infection and the expression of p53 and proliferating cell nuclear antigen (PCNA) in Raised Erosive Gastritis (REG) with a view to better guiding Chinese and Western medicine Combined with control REG. [Methods] Sixty-three patients with REG syndrome of traditional Chinese medicine (TCM syndrome differentiation of spleen and stomach damp-heat syndrome, spleen-qi deficiency syndrome and spleen-deficiency syndrome of damp-heat syndrome) were selected and 18 cases of normal control (normal) group were enrolled. All subjects underwent endoscopy, Rapid urease test and histological staining were used to detect Hp, p53 and PCNA. [Results] The expression of p53 and PCNA in various syndromes of REG group were significantly higher than those in normal group (all P <0.01). There was no significant difference in the expression of p53 and PCNA in each syndrome (P> 0.05) There was no significant difference in the positive expression of p53 and PCNA between syndrome Hp positive and Hp negative (all P> 0.05). [Conclusion] The gastric mucosa of REG is highly proliferative. There was no significant difference between REG, Hp infection and p53, PCNA expression in various TCM TCM syndrome types.