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目的:探讨Survivin基因-31C/G多态性和子痫前期的发病及其严重程度的相关性。方法:采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术以96例患有子痫前期的孕妇(其中轻度子痫前期52例,重度子痫前期44例)和110例在郑州大学第二附属医院、郑州市妇幼保健院进行产前检查并分娩的正常孕妇为研究对象,检测Survivin基因-31C/G多态性分布的基因型。结果:G等位基因型频率在子痫前期组高于对照组(P<0.05),G等位基因型频率在重度子痫前期组高于轻度子痫前期组(P<0.05)。结论:Survivin基因-31C/G多态性的G等位基因可能是中原地区汉族妇女发生子痫前期的遗传危险因素,并与病情严重程度有关。
Objective: To investigate the correlation between the -31C / G polymorphism of Survivin gene and the incidence and severity of preeclampsia. Methods: Ninety-six pregnant women with mild preeclampsia (52 with mild preeclampsia, 44 with severe preeclampsia) and 110 with preeclampsia (n = 110) were studied by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) In the Second Affiliated Hospital of Zhengzhou University, Zhengzhou Municipal Maternal and Child Health Hospital for prenatal care and delivery of normal pregnant women as the research object, detection of Survivin gene -31C / G polymorphism distribution genotype. Results: The frequency of G allele in preeclampsia group was higher than that in control group (P <0.05). The frequency of G allele in severe preeclampsia group was higher than that in mild preeclampsia group (P <0.05). CONCLUSION: The G allele of -31C / G polymorphism of Survivin gene may be the genetic risk factor of preeclampsia in Han women in Central Plains and is related to the severity of the disease.