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JunD是一种属于多功能激活剂蛋白-1(activating protein-1,AP-1)家族的转录因子,可以激活或抑制多种靶基因的表达.在生长发育过程中,在各种细胞类型中都呈现出组成性表达.近20年的临床数据及分子生物学研究表明,JunD蛋白的功能受多个复杂过程调控,包括转录控制、转录后调节、蛋白质翻译后修饰及蛋白-蛋白相互作用等.JunD基因表达的精细调控及JunD蛋白与其它蛋白之间的相互作用可调节细胞增殖、分化和凋亡等过程.JunD蛋白活性异常会导致肿瘤、代谢及病毒类疾病的发生.JunD蛋白的转录激活及抑制受1个复杂调控网络调控,在这个网络调节下,JunD蛋白在细胞的生长调控过程中发挥重要作用.本文就JunD基因表达的调控机制及其与肿瘤之间关系的最新研究进展做一综述.
JunD is a transcription factor belonging to the activating protein-1 (AP-1) family that activates or inhibits the expression of multiple target genes.During growth and development, JunD is involved in various cell types Have shown constitutive expression.Many clinical data and molecular biological studies in recent 20 years show that the function of JunD protein is regulated by a number of complex processes including transcriptional control, post-transcriptional regulation, post-translational modification of protein and protein-protein interaction The fine regulation of JunD gene expression and the interaction between JunD protein and other proteins can regulate the process of cell proliferation, differentiation and apoptosis, etc. The abnormal activity of JunD protein can lead to tumor, metabolism and viral diseases.JunD protein transcription Activation and inhibition by a complex regulatory network regulation, under the regulation of the network, JunD protein plays an important role in the regulation of cell growth.In this paper, the regulatory mechanism of JunD gene expression and the relationship between tumor and the latest research progress A review.