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凝血酶敏感蛋白 1(thrombospondin 1,TSP 1)是重要的多肽类内源性血管新生抑制物。TSP 1的抗血管新生活性主要由其第 2和第 3个备解素样 (type 1repeats)重复顺序承担 ;P5 3蛋白是TSP 1基因的关键转录调节因子 ;CD36分子介导的内皮细胞凋亡是TSP 1抑制血管新生作用的重要机制 ;TSP 1的编码序列可以作为有效的抗血管新生基因药物
Thrombospondin 1 (TSP 1) is an important polypeptide endogenous angiogenesis inhibitor. The antiangiogenic activity of TSP 1 is mainly borne by its 2nd and 3rd repeat repeats of type 1 repeats; P5 3 protein is a key transcriptional regulator of TSP 1; CD36-mediated endothelial cell apoptosis Death is an important mechanism by which TSP 1 inhibits the effects of angiogenesis; the coding sequence of TSP 1 can be used as a potent anti-angiogenic gene drug