一、N-取代唑类化合物概况我们从一个结构假设出发研究唑类化合物的杀菌活性,即:在活体内能形成正碳离子的化合物可能表现出生物活性。基于这一设想,N-三苯甲基咪唑是引人注目的化合物。正如在N-酰基咪唑中,π-体系中酰胺氮的孤电子对可提高酰碳的反应活性一样,使用N-三苯甲基咪唑也会有助于活性三苯甲基正离子的形成(图1) I. N-Substituted Azoles Overview We investigated the bactericidal activity of azoles from a structural assumption that compounds that form n-carbon ions in vivo may exhibit biological activity. Based on this idea, N-trityl imidazole is a notable compound. Just as in N-acylimidazoles, the lone pair of amide nitrogen in the π-system increases the acyl-carbon reactivity, the use of N-tritylimidazole also contributes to the formation of active trityl-cations figure 1)