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目的研究涎腺恶性肿瘤Ｅ－钙粘蛋白（Ｅ－ｃａｄｈｅｒｉｎ．Ｅ－ＣＤ）的表达情况，评估其与涎腺恶性肿瘤的局部浸润和淋巴结转移的关系。方法选取４０例涎腺粘液表皮样癌、３７例腺样囊性癌、８例恶性混合瘤，以抗Ｅ－ＣＤ多克隆抗体用ＰＡＰ法进行免疫组织化学染色和半定量分析。结果正常涎腺导管上皮及良性肿瘤细胞Ｅ－ＣＤ表达正常，而８１．２％（６９／８５例）涎腺恶性肿瘤Ｅ－ＣＤ表达减弱或消失。Ｅ－ＣＤ的失表达主要发生于有神经或血管浸润的腺样囊性癌（Ｐ＜０．０５）及有淋巴结转移的涎腺恶性肿瘤（Ｐ＜０．０５）。结论Ｅ－ＣＤ的存在与否可能决定涎腺恶性肿瘤的局部浸润和淋巴结转移。
Objective To study the expression of E-cadherin (E-CD) in salivary gland malignant tumor and evaluate the relationship between the expression of E-cadherin and local lymph node metastasis in salivary gland malignant tumor. Methods 40 cases of mucoepidermoid carcinoma of the salivary gland, 37 cases of adenoid cystic carcinoma and 8 cases of malignant mixed tumor were selected for immunohistochemical staining and semi-quantitative analysis using anti-E-CD polyclonal antibody. Results The expression of E-CD in normal salivary gland ductal epithelium and benign tumor cells was normal, while the expression of E-CD in 81.2% (69/85) salivary gland malignancies decreased or disappeared. Loss of E-CD mainly occurred in adenoid cystic carcinoma with nerve or vascular invasion (P <0.05) and salivary gland malignancy with lymph node metastasis (P <0.05). Conclusion The existence of E-CD may determine the local invasion and lymph node metastasis of salivary gland malignant tumor.