目的：观察胎鼠宫内缺血缺氧后脑组织Ｂｃｌ－２、Ｂａｘ 表达的动态变化。方法：钳夹一侧供应子宫的血管１０ｍ ｉｎ 造成宫内缺血缺氧模型，分别再灌注０，１，４，８，１５，２４ ｈ，进行半定量ＲＴ－ＰＣＲ检测Ｂｃｌ－２与Ｂａｘｍ ＲＮＡ 的表达。结果：Ｂａｘ 的表达在缺血缺氧当时即开始增强， ４ ｈ 已有显著性（Ｐ＜ ０．０１）， ８ ｈ 达高峰， １５ ｈ 有所降低， ２４ ｈ 又出现升高（ Ｐ＜ ０．０１）；而Ｂｃｌ－２的变化无显著性（Ｐ＞ ０．０５）；Ｂｃｌ－２与Ｂａｘ 的比值在８ ｈ 达最低。结论：在轻度宫内缺血缺氧后４ ｈ，Ｂａｘ 发生显著变化 OBJECTIVE: To observe the dynamic changes of Bcl-2 and Bax expression in fetal rat brain after intrauterine ischemia and hypoxia. Methods: The intrauterine ischemia and hypoxia model was induced by uterine blood supply of 10 mins on the side of clamp, and then reperfused for 0, 1, 4, 8, 15 and 24 h respectively. Semiquantitative RT-PCR was used to detect the expression of Bcl- expression. Results: The expression of Bax began to increase at the time of hypoxia and hypoxia, and reached a peak at 4 hours (P <0.01). It peaked at 8 hours and decreased at 15 hours (P <0.01) .01), while the change of Bcl-2 was not significant (P> 0.05). The ratio of Bcl-2 to Bax was the lowest at 8 h. CONCLUSION: Bax changes significantly at 4 h after mild intrauterine ischemia and hypoxia