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目的观察联合运用奥美拉唑及雷尼替丁治疗难治性胃食管反流病(GERD)的疗效。方法将难治性GERD23例,于清晨空腹服用奥美拉唑20mg,夜间临睡前服用雷尼替丁300mg,疗程8周。治疗前及疗程结束后,由专人行胃镜检查,观察登记食管炎及反流症状的改善程度。结果症状评价:显效17例,有效5例,无效1例,总有效率95.7%。胃镜评价:除外2例非糜烂性反流病(NERD)外,21例中显效12例,有效8例,无效1例,总有效率95.2%。结论奥美拉唑及雷尼替丁联合治疗难治性GERD有较好的疗效,可作为难治性GERD的常规治疗方案供临床使用。
Objective To observe the efficacy of omeprazole and ranitidine in the treatment of refractory gastroesophageal reflux disease (GERD). Methods Twenty-three patients with refractory GERD were treated with omeprazole 20 mg in the fasting morning and 300 mg ranitidine before going to sleep at night. The course of treatment was 8 weeks. Before treatment and after the end of treatment, by special line gastroscopy to observe the esophagitis registered and improvement of reflux symptoms. Results Symptom evaluation: markedly effective in 17 cases, effective in 5 cases, ineffective in 1 case, the total effective rate was 95.7%. Gastroscopy evaluation: Except 2 cases of non-erosive reflux disease (NERD), 21 cases markedly effective in 12 cases, effective in 8 cases, 1 case of ineffective, the total effective rate was 95.2%. Conclusion Omeprazole and ranitidine combined treatment of refractory GERD has a good effect, can be used as a routine treatment of refractory GERD clinical use.