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目的分析腹型肥胖与体内炎性因子水平及代谢综合征(MS)之间的关系,探讨儿童腹型肥胖的科学治疗方法。方法以该院儿科门诊2014年1月-2015年12月接诊的128例单纯性肥胖儿童为研究对象,根据腰围数据进行划分,设腹型组与非腹型组两组。同时对研究对象的体重、身高、臀围(H)、腰围(W)进行测量。采集各研究对象的空腹血并检测其血糖、血脂、超敏C反应蛋白(Hs-CRP)和内脂素水平。结果腹型组体质指数(BMI)、W、腰臀比(WHR)均明显高于非腹型组差异有统计学意义(t=4.85、3.82、3..08,均P<0.05);腹型组MS检出率明显高于非腹型组,差异有统计学意义(χ~2=12.119,P<0.05);腹型组Hs-CRP及内脂素水平明显高于非腹型组,差异有统计学意义(t=4.612、4.121,均P<0.05);两组高血压、高血糖、高甘油三酯(TG)血症、低高密度脂蛋白胆固醇(HDL-C)血症的人数比较差异均有统计学意义(χ~2=8.82、9.15、14.71、7.41,均P<0.05)。结论在肥胖儿童中,较之非腹型肥胖儿童,腹型肥胖儿童MS患病几率更高;儿童腹部脂肪分布与体内炎症因子及TG的增高有着密切关系。因此,应对腹型肥胖进行积极防治。
Objective To analyze the relationship between abdominal obesity and inflammatory cytokines in vivo and metabolic syndrome (MS), and to explore the scientific treatment of abdominal obesity in children. Methods A total of 128 simple obese children admitted from January 2014 to December 2015 in pediatric outpatient department of the hospital were divided into two groups according to their waistline data: abdominal group and non-abdominal group. At the same time, the body weight, height, hip circumference (H), waist circumference (W) were measured. Fasting blood of each subject was collected and blood glucose, lipids, Hs-CRP and visfatin were measured. Results The body mass index (BMI), W, WHR of the abdominal group were significantly higher than those of the non-abdominal group (t = 4.85,3.82, 3.08, all P <0.05) (Χ ~ 2 = 12.119, P <0.05). The levels of Hs-CRP and visfatin in abdominal group were significantly higher than those in non-abdominal group, The difference was statistically significant (t = 4.612, 4.121, both P <0.05); two groups of hypertension, hyperglycemia, hypertriglyceridemia, low-density lipoprotein cholesterol The difference was statistically significant (χ ~ 2 = 8.82,9.15,14.71,7.41, all P <0.05). Conclusion Compared with non-abdominal obese children, the incidence of MS in abdominal obesity children is higher than that in non-abdominal obese children. The distribution of abdominal fat in children is closely related to the increase of inflammatory factors and TG in children. Therefore, active prevention and treatment of abdominal obesity should be carried out.