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目的研究内皮型一氧化氮合酶(endothelium-type nitric oxide synthase,eNOS)在慢性乙型肝炎肝组织中的表达及其与病理改变的关系。方法应用免疫组化法观察了41例慢性乙型肝炎患者肝组织中eNOS的变化。结果 eNOS见于肝细胞,窦内皮细胞,枯否细胞,血管内皮细胞,单个核细胞,及增生的卵圆细胞,呈胞浆型,细颗粒型,粗颗粒型及胞膜型分布,以肝细胞为主,在炎症病变活动区相对集中。并发现其表达随肝组织病变活动程度增加而增强,与炎症程度的相关系数为0.5327(P<0.05),与纤维化程度无明显相关性。结论 eNOS与慢性乙肝肝组织病理改变密切相关。
Objective To investigate the expression of endothelin-1 (nNOS) in chronic hepatitis B liver tissue and its relationship with pathological changes. Methods The changes of eNOS in liver tissue of 41 patients with chronic hepatitis B were observed by immunohistochemistry. Results eNOS was found in hepatocytes, sinus endothelial cells, Kupffer cells, vascular endothelial cells, mononuclear cells and hyperplastic oval cells, showing cytoplasmic, fine granular, coarse granular and membranous distribution, Mainly in the inflammatory lesion activity area is relatively concentrated. And found that the expression increased with the degree of activity of liver tissue increased, with a correlation coefficient of 0.5327 (P <0.05), and no significant correlation with the degree of fibrosis. Conclusion eNOS is closely related to the pathological changes of chronic hepatitis B liver tissue.