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目的探讨使用150IU/天的促卵泡刺激素联合GnRH拮抗剂方案在卵巢低反应患者行体外受精-胚胎移植中的应用价值。方法对139周期卵巢低反应患者行体外受精-胚胎移植时使用低剂量促卵泡刺激素联合GnRH拮抗剂方案的临床资料进行回顾性分析。结果起始周期139周期,取卵126周期,移植109周期,周期取消率为21.58%。促卵泡刺激素激素平均使用量为1259.09±282.51IU,平均拮抗剂使用量为0.78±0.26mg。共获卵506个、成熟卵子数为438个、胚胎305个,优质胚胎数184个。平均每取卵周期获卵数4.02±2.51个,胚胎2.46±1.49个,优质胚胎数1.46±1.43个。平均每周期移植胚胎数为1.86±0.67个。临床妊娠45例,每移植周期临床妊娠率为41.28%,着床率为26.60%。≤35岁组的获卵数、妊娠率、着床率较≥40岁组明显增高,有显著性差异。各年龄组中拮抗剂用量、促性腺激素用量、成熟卵子数、胚胎数、优质胚胎数及移植胚胎数均无显著性差异。结论 1.150IU/天低剂量促卵泡刺激素联合GnRH拮抗剂方案是治疗卵巢低反应者的有效治疗方案;2.年龄是影响体外受精胚胎移植结局的重要因素。
Objective To investigate the value of 150IU / day follicle-stimulating hormone combined with GnRH antagonist in IVF-ET in patients with low ovarian response. Methods The clinical data of 139 patients with low response ovarian follicle stimulating hormone combined with GnRH antagonist undergoing IVF in embryo transfer were retrospectively analyzed. The results of the initial cycle of 139 cycles, 126 cycles of ovulation, 109 cycles of transplantation, cycle cancellation rate of 21.58%. Follicle-stimulating hormone hormone average use of 1259.09 ± 282.51IU, the average amount of antagonist 0.78 ± 0.26mg. A total of 506 eggs were obtained, with 438 mature eggs, 305 embryos and 184 high quality embryos. The average number of oocytes retrieved per egg retrieval cycle was 4.02 ± 2.51, 2.46 ± 1.49 embryos and 1.46 ± 1.43 high quality embryos. The average number of embryos transferred per week was 1.86 ± 0.67. Clinical pregnancy in 45 cases, the clinical pregnancy rate per transplant cycle was 41.28%, the implantation rate was 26.60%. The number of oocytes in ≤35 years old group, pregnancy rate and implantation rate were significantly higher than those of ≥40 years old, with significant difference. Antagonist dosage, gonadotrophin dosage, number of mature eggs, number of embryos, number of high quality embryos and number of embryos transferred did not differ significantly in all age groups. Conclusion 1.150IU / day low dose follicle stimulating hormone combined with GnRH antagonist regimen is an effective treatment for patients with low ovarian response; 2. Age is an important factor affecting the outcome of in vitro fertilization embryo transfer.