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百日咳菌苗是早在1912年由 Nicolle 和 Conner 两人首先研究。以后的卅余年中,国外学者对本菌苗的制造方法和预防效果进行了许多次的讨论和研究。我国在解放以前已有吴瑞萍氏等研究这个问题,但是本菌苗的大力制造和推广毕竟是1949年全国解放以后才实现的。十三年来,百日咳菌苗的产量逐渐增加,制造方法显著改进,接种数量有所增多。这种情况下,迫切要求对国产的本菌苗的预防效果进行研究和评价。
Bordetella pertussis vaccine was first studied by Nicolle and Conner as early as 1912. After more than a year, foreign scholars conducted many discussions and studies on the manufacturing methods and preventive effects of the vaccine. Before the liberation of our country, Wu Ruiping et al. Had studied this issue, but the vigorous manufacture and promotion of this bacterin was realized after the liberation of 1949 in China. Over the past thirteen years, the yield of pertussis vaccine has been gradually increasing, the manufacturing methods have been significantly improved, and the number of vaccinations has increased. Under such circumstances, it is urgent to study and evaluate the preventive effect of domestic bacterins.