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This paper reports general and special to-xicological experiments on Qinghaosu and itsderivatives.Results point to the superiority ofQinghaosu and its derivatives over chloroquinein such respects as therapeutic index,marginof safety and side effects.It is pertinent there-fore to recommend these compounds for clinicaltrial as antimalarials.The main toxic effects of Qinghaosu weremanifested on the hemopoietic system,especial-ly the erythroid series,and the myocardium wassomewhat involved.These toxic reactions werehowever reversible.The teratogenicity experi-ments in mice and rats showed both Qinghaosuand artemether to be embryo-toxic,and clinicaltrials should take into account these toxic ef-fects.Further studies with various other animalspecies should be aimed at discovering whetherspecies differences exist.
This paper reports general and special to-xicological experiments on Qinghaosu and its derivatives. Results point to the superiority ofQinghaosu and its derivatives over chloroquinein such respects as therapeutic index, marginof safety and side effects. It is pertinent there-fore to recommend these compounds for clinicaltrial as antimalarials. The main toxic effects of Qinghaosu weremanifested on the hemopoietic system, especial-ly the erythroid series, and the myocardium wassomewhat involved. these toxic reactions were show reversible. the teratogenicity experi-ments in mice and rats showed both Qinghaosu and artemether to be embryo -toxic, and clinicaltrials should take into account these toxic ef-fects.Further studies with various other animalspecies should be aimed at discovering whetherspecies differences exist.