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目的探讨用单休素氢质子磁共振(~1H MR)波谱诊断口腔颌面部软组织恶性肿瘤的可行性。方法回顾分析42例经~1H MR 检查并经病理证实为软组织恶性肿瘤的病例。~1H MR 波谱空间定位采用点分辨波谱法,同波时间144 ms。以肿瘤内胆碱化合物(化学位移为3.2×10~(-6))的检出为评价标准。结果 42例恶性肿瘤中,检出胆碱化合物者37例,包括15例鳞状细胞癌,9例涎腺癌,13例肉瘤和恶性淋巴瘤。结论单休素~1H MR 波谱能为口腔颌面部软组织恶件肿瘤的诊断提供有益信息。多数恶性肿瘤以含胆碱化合物为特点,其中肉瘤和恶性淋巴瘤内胆碱化合物的检出高于上皮性癌。
Objective To investigate the feasibility of single-molecule hydrogen proton magnetic resonance (~ 1H MR) spectroscopy in the diagnosis of oral and maxillofacial soft tissue malignancies. Methods The clinical data of 42 cases with ~ 1H MR examination and pathologically confirmed as soft tissue malignancy were retrospectively analyzed. ~ 1H MR spectroscopy spatial resolution using point-resolved spectroscopy, the same wave time 144 ms. Tumor in the choline compound (chemical shift of 3.2 × 10 -6) was detected as the evaluation criteria. Results Of 42 malignant tumors, 37 cases were found choline compounds, including 15 cases of squamous cell carcinoma, 9 cases of salivary gland carcinoma, 13 cases of sarcoma and malignant lymphoma. Conclusion Single isotope ~ 1H MR spectroscopy can provide useful information for the diagnosis of malignant tumors of oral and maxillofacial soft tissue. Most malignancies are characterized by choline-containing compounds, of which choline and malignant lymphoma are more detectable than epithelial carcinomas.