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目的:观察血清胱抑素C(CysC)含量在颅脑损伤继发肾功能损害中的临床价值。方法:采用乳胶颗粒增强免疫透射比浊法(PETIA)检测51例颅脑损伤继发肾功能损害患者血清CysC,同时检测血清肌酐(SCr)、尿素氮(Bun)、尿酸(UA)含量,并与41例健康体检者进行对照分析。结果:颅脑损伤继发肾功能损害患者组血清CysC水平和CysC异常检出率均明显高于健康体检对照组(P<0.01);患者组血清CysC的异常检出率明显高于同组血清SCr、UA和Bun(P<0.01),但在对照组中,血清CysC、血清CysC、血清肌酐(SCr)、尿素氮(Bun)、尿酸(UA)的异常检出率无差别(P>0.05)。结论:颅脑损伤继发肾功能损害时血清CysC较其他肾功指标更敏感,可以把血清Cys C做为其肾功能早期诊断的一个首选指标。
Objective: To observe the clinical value of serum cystatin C (CysC) content in patients with traumatic brain injury secondary to renal dysfunction. Methods: Serum CysC was detected in 51 patients with traumatic brain injury secondary to renal dysfunction by latex particle enhanced immunoturbidimetric assay (PETIA). Serum creatinine (SCr), blood urea nitrogen (BUN) and uric acid (UA) And 41 cases of healthy subjects for controlled analysis. Results: The detection rates of serum CysC and CysC abnormalities in patients with traumatic brain injury secondary to renal dysfunction were significantly higher than those in healthy controls (P <0.01). The abnormalities of serum CysC in patients with renal dysfunction were significantly higher than those in the same group SCr, UA and Bun (P <0.01). However, there was no difference in the detection rate of CysC, CysC, SCr, UU and Bun in the control group ). CONCLUSION: Serum CysC is more sensitive than other indexes of renal function in patients with traumatic brain injury secondary to renal dysfunction. Serum Cys C can be used as a preferred index for early diagnosis of renal function.