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芦氟沙星(Rufloxacin)为一新型氟喹诺酮类抗生素。具有对G~+、G~-需氧菌的广谱抗菌活性。同时具有特殊的药动学性质,如口服吸收好,半衰期长达30h,以及良好的组织分布。由此,芦氟沙星作为每日一次的泌尿道和呼吸道用药。 Guffini等和Sastry等对该药的免疫调节作用进行了研究。本文就他们的研究情况做一介绍。 体外免疫调节作用研究 用0.5MIC芦氟沙星、克雷伯氏肺炎杆菌、人巨噬细胞共孵育,1h开始至72h的孵育期间,巨噬细胞对细菌的吞噬作用显著增加,共吞噬速度以两倍于未用该药处理的细菌的速度进行(P<0.01)。且使细胞内数量减少60～97％。
Rufloxacin is a novel fluoroquinolone antibiotic. Has broad-spectrum antibacterial activity against G ~ +, G ~ - aerobic bacteria. At the same time has a special pharmacokinetic properties, such as oral absorption, half-life up to 30h, and good tissue distribution. As a result, rufloxacin is used as a daily urinary and respiratory drug. Guffini et al. And Sastry et al. Studied the immunomodulatory effects of this drug. This article gives an introduction of their research. In vitro immunomodulatory effects of 0.5MIC rufloxacin, Klebsiella pneumoniae, human macrophages were co-incubated 1h start to 72h incubation period macrophages phagocytosis of bacteria increased significantly, the total phagocytosis rate Twice as fast as the bacteria not treated with this drug (P <0.01). And reduce the number of intracellular 60 ~ 97%.