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新生儿长期、反复惊厥的治疗较为棘手。本研究采用脑功能监测仪(CFM)评估了利多卡因对新生儿顽固性惊厥的治疗效果。方法 46例均来自1980～1986年瑞典某NICU的反复惊厥者。胎龄25～43周,出生体重800～4830g,年龄0～29天。早产婴17例,足月儿29例。惊厥的主要原因为出生时窒息25,颅内出血9,脑膜炎4,器质性心脏病1,几乎误诊的婴儿猝死综合征2,代谢性疾患1和败血症1,不明原因惊厥3(例)。所有患儿均用过苯巴比妥治疗(首剂负荷量10～15mg/kgi.v,继以6 mg/kg/天静滴维持),均无效。其中22例加用了安定1剂(1～2 mg/kg),仍反复惊厥。低血糖和低血钙者除给予1次大剂量苯巴比妥外,还分别静脉输注10%葡萄糖和氯化钙。不明原因惊厥加用维生素B_6100mg静脉注射。治疗前后所有患儿均用
Long-term neonatal treatment of recurrent seizures more difficult. This study used brain function monitor (CFM) to assess the therapeutic effect of lidocaine on neonatal refractory convulsions. Methods 46 cases were from repeated episodes of convulsions in a NICU from 1980 to 1986 in Sweden. Gestational age of 25 to 43 weeks, birth weight 800 ~ 4830g, age 0 ~ 29 days. 17 cases of premature infant, full-term children in 29 cases. The main causes of convulsions are asphyxia at birth 25, intracranial hemorrhage 9, meningitis 4, structural heart disease 1, sudden misdiagnosis of sudden infant death syndrome 2, metabolic disorders 1 and sepsis 1, and unexplained convulsions 3 (case). All children were treated with phenobarbital (first dose of 10 ~ 15mg / kgi.v, followed by 6mg / kg / day intravenous maintenance), were ineffective. Of which 22 cases plus a stability of 1 (1 ~ 2 mg / kg), is still repeated seizures. Hypoglycemia and hypocalcaemia in addition to giving a large dose of phenobarbital, but also intravenous infusion of 10% glucose and calcium chloride. Unexplained convulsions plus vitamin B_6100mg intravenous injection. Before and after treatment, all children were used