论文部分内容阅读
自从1963年以来,先锋霉素Ⅰ(cephalothin)及Ⅱ(cephaloridine)均广泛用于各种细菌感染。但其对细菌性脑膜炎的疗效尚未肯定。本文综合了文献用先锋霉素类治疗细菌性脑膜炎106例的资料,阐明其疗效,并作为对青霉素过敏病人选择替换药物的指导。其中34例用先锋霉素Ⅰ注射,均未作鞘内用药。仅14例(41％)效果良好;20例(59％)不成功。13例脑膜炎发展或脑脊液培养持续阳性,7例在治疗中临床上恶化。这20例中的13例由于临床疗效不好而使用了其他抗菌素。6
Since 1963, cephalothin and cephaloridine have been widely used in various bacterial infections. However, the efficacy of bacterial meningitis is not yet confirmed. This article combines the literature using Pioneermycin class of bacterial meningitis treatment of 106 cases of data to clarify its efficacy, and as a penicillin allergic patients choose to guide the replacement of drugs. Among them, 34 cases were injected with cephalosporin I, and no intrathecal administration was given. Only 14 (41%) had a good effect; 20 (59%) did not. Thirteen cases of meningitis developed or cerebrospinal fluid cultures were consistently positive and seven were clinically deteriorated in treatment. Thirteen of these 20 patients used other antibiotics due to poor clinical outcomes. 6