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目的:探讨抗抑郁治疗对老年高血压患者降压疗效的影响。方法:观察85例老年高血压合并抑郁症状的患者随机分为2组,所有患者均给予钙拮抗剂(氨氯地平5mg/d)、血管紧张素转化酶抑制剂(贝那普利10mg/d),抗抑郁治疗组在此基础上加用帕罗西丁20mg/d。结果:抗抑郁治疗组其降压幅度,降压有效率,汉密尔顿抑郁量减分率均优于治疗前及对照组,差异显著有统计学意义(P<0.05)。结论:抗抑郁治疗可增强老年高血压合并抑郁患者的降压效果。
Objective: To investigate the effect of antidepressant on the antihypertensive effects in elderly hypertensive patients. Methods: A total of 85 elderly hypertensive patients with depressive symptoms were randomly divided into 2 groups. All patients were given calcium antagonist (amlodipine 5mg / d), angiotensin converting enzyme inhibitor (benazepril 10mg / d ), Antidepressant treatment group on the basis of plus paroxetine 20mg / d. Results: The antihypertensive treatment group had better antihypertensive efficacy, antihypertensive efficacy rate and Hamilton depression reduction rate than those before treatment and control group, the difference was statistically significant (P <0.05). Conclusion: Antidepressant treatment can enhance the antihypertensive efficacy in elderly patients with hypertension and depression.