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目的:初步了解甘肃省病毒性脑炎的病原种类及其分布特征。方法:用ELISA方法对2006年-2009年甘肃省5个地、州、市送检的209例临床诊断为病毒性脑炎患者的急性期血清和脑脊液标本,检测乙脑病毒IgM抗体,然后对乙脑IgM抗体阴性的所有血清、脑脊液标本检测其它6种常见病毒IgM抗体。结果:经血清学及脑脊液检测,209例患者中的154例(73.7%)检测出病毒特异性IgM抗体,构成顺序为乙脑病毒(16.7%)、呼吸道合胞病毒(15.8%)、腮腺炎病毒(13.4%)柯萨奇病毒(9.6%)、埃可病毒(9.1%)、单纯疱疹病毒(8.1%)、水痘-带状疱疹病毒(1.0%)。结论:乙脑病毒及呼吸道合胞病毒是甘肃省病毒性脑炎的主要病原体,腮腺炎病毒次之,柯萨奇病毒、埃可病毒、单纯疱疹病毒也是重要的抗原。
Objective: To understand the pathogens and distribution of viral encephalitis in Gansu Province. Methods: A total of 209 cases of acute encephalitis and cerebrospinal fluid were collected from 5 prefectures, cities and prefectures in Gansu Province from 2006 to 2009. The IgM antibodies against JE virus were detected by ELISA. JE IgM antibody-negative serum and cerebrospinal fluid specimens of other six common viral IgM antibodies. Results: Serum-specific and IgM antibodies were detected in 154 of 209 patients (73.7%) by serological and cerebrospinal fluid tests in the order of JEV (16.7%), respiratory syncytial virus (15.8%), mumps Coxsackievirus (9.6%), echovirus (9.1%), herpes simplex virus (8.1%), varicella-zoster virus (1.0%) were also reported. Conclusion: Japanese encephalitis virus and respiratory syncytial virus are the main pathogens of viral encephalitis in Gansu Province. Mumps virus secondarily, coxsackie virus, echovirus and herpes simplex virus are also important antigens.