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2-Phenoxy-4H-spiro{naphtho[2,3-e][1,4,2]oxazaphosphinane-5,10-dione,1’-cyclo- hexane}2-oxide (C22H20NO5P) was synthesized by the Mannich-type reaction of 2-amino-3- hydroxy-1,4-naphthoquinone with phenyl phosphorodichloridite and cyclohexanone, and struc- turally characterized by single-crystal X-ray diffraction analysis. It crystallizes in monoclinic, space group P21/n with a = 7.9133(11), b = 13.0269(18), c = 19.091(3) , β = 101.906(2)°, V = 1925.6(5) 3, Z = 4, Mr = 409.36, Dc = 1.412 g/cm3, F(000) = 856, μ = 0.178 mm-1, S = 1.015, the final R = 0.0381 and wR = 0.0906 for 2718 observed reflections with I > 2((I) and 262 variable parameters. This compound may be used as DNA-intercalator. Its cytotoxic activities were also tested in vitro on four human tumor cell lines.
Cyclooctane} 2-oxide (C22H20NO5P) was synthesized by the Mannich- type reaction of 2-amino-3-hydroxy-1,4-naphthoquinone with phenyl phosphorodichloridite and cyclohexanone, and struc- turally characterized by single-crystal X-ray diffraction analysis. It crystallizes in monoclinic space group P21 / n with a = B = 13.0269 (18), c = 19.091 (3) β, β = 101.906 (2) °, V = 1925.6 (5) 3, Z = 4, Mr = 409.36, Dc = 1.412 g / the final R = 0.0381 and wR = 0.0906 for 2718 at reflections with I> 2 ((I) and 262 variable parameters. This compound may be used as DNA-intercalator. Its cytotoxic activities were also tested in vitro on four human tumor cell lines.